Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Numerous studies have shown extracts of red clover to be safe and effective for hot flashes in particular. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. Red clover is a wild plant belonging to the legume family. Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. They are found in legumes, such as soy and red clover (RC) and mimic the actions of estrogen through ER binding and activation of ER-dependent gene transcription . Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Red clover is used to purify blood by enhancing urine, production of mucous, enhancing circulation and stimulating bile secretion. 2010;76:896-904. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. Acute-on-chronic subdural hematoma in a patient taking Red Clover herbal supplement: A case report. Red Clover Basics. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. Firstly, some proponents of its use have suggested that it is effective enough to be used on its own. Isoflavones have generated considerable interest in the last decade because of their possible cancer-preventive, cardioprotective. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Because red clover contains isoflavones that mimic the effects of the hormone estrogen once they enter the body, the safety of RC in patients with breast or endometrial cancer remains controversial. An isoflavone extract is widely promoted as a dietary supplement to relieve menopausal symptoms. Compounds in red clover include phytoestrogenic isoflavones such as genistein, diadzen, formononetin and biochanin A. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. The formula was developed after his grandfather observed what sick horses grazed on to restore their health. In the best selling herbal classic Back to Eden, author Jethro Kloss declares red clover as a life-saving anti-cancer remedy. Red clover contains substances called isoflavones. 2002;42:187-93. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Potential uses: Red clover is used to treat menopausal symptoms and breast pain. All rights reserved. The plant was thought to purify the blood by promoting urine and mucus production, improving circulation, and stimulating secretion of bile. Her symptoms resolved after discontinuation of the supplement.. If youve wondered what benefit this herb has, youre not alone. Br J Nutr. Wang Y, Man Gho W, Chan FL, et al. Also known as: Daidzein, genistein, isoflavone, phytoestrogen, purple clover, trefoil, trifolium, beebread, clovone. The loss of elasticity can contribute to increased blood pressure, causing the heart to work harder. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. The chemical and biologic profile of a red clover (, Long-term pharmacokinetics of an extract of isoflavones from red clover (. Statements made about products have not been evaluated by the Food and Drug Administration. Red clover (Trifolium pratense L.) is a plant in the Fabaceae botanical family. Red Clover is not suitable for patients with hormone diseases such as breast, uterine, ovarian cancer or endometriosis. BCA has been reported to prevent various cancers including prostate, breast, and colon cancer. In another, the patient required intensive medical interventions to resolve issues. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. It is not recommended for women with estrogen-receptor-positive breast cancer. Also, red clover may increase the effects of anticoagulants and antiplatelet drugs. Coon JT, Pittler MH, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Otherwise there is no stand Clinical data show that supplementation with red clover isoflavones improves menopausal symptoms compared with placebo (7) (8), but systematic reviews are mixed (9) (24) (10). In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Its active ingredients include phytoestrogens. Bleeding disorders: Red clover might increase the chance of bleeding.  Further research is needed to determine the safety and efficacy of this agent. Red Clover Uses. Hasan Y, Schoenherr D, Martinez AA, et al. Red clover contains substances called isoflavones. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved t … Effects of red clover extracts on breast cancer cell migration and invasion Gynecol Endocrinol. Subarachnoid hemorrhage was reported in a 53-year-old woman following use of an herbal supplement that contained red clover, dong quai, and Siberian ginseng, which she took for hot flashes associated with perimenopause. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. Patients taking hormonal contraceptives should not use clover, as this may reduce the effect of contraception. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Among classic herbalists, red clover is known as one of the world’s oldest and most common natural herbal supports for the treatment for all varieties of cancer — anywhere in the body. Of concern are findings that red clover inhibits the growth of normal prostate cells and increases resistance of prostate cancer cells to high-dose radiation in vitro (15). It is important that we be clear on the research. Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. Subdural hematoma: In a 65-year-old woman with no other risk factors for bleeding except long-term use of red clover supplements for postmenopausal symptoms. 11. There is no evidence that red clover can help treat cancer. Red Clover tea, made from the red blossoms, was an old remedy for winter colds. Red Clover’s Anti-Cancer Effects Red clover contains a weak phytoestrogen called formononetin. 2005;11:60-65. 9. The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. Red clover is a reserve of protein and unique phytochemicals. Biochanin A (BCA) is a dietary isoflavone present in red clover. 2008;99:303-10. The June 2004 edition of Breast Cancer Research states that “red clover does not cause any estrogenic increase in breast density, while human and synthetic estrogen does. Dried red clover flowers have been used in traditional medicine to treat a wide variety of ailments, including jaundice, cancer, breast tissue infections, joint disorders, and respiratory conditions (e.g, whooping cough, bronchial asthma), and as a sedative. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. Potential interactions between alternative therapies and warfarin. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved to be effective in reducing vasomotor symptoms in a number of studies. Use of this Web site does not create an expressed or implied physician-patient relationship. 2005;21:257-64. 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Overview. Red clover is an herbal supplement used orally for conditions such as menopausal symptoms and hot flashes, mastalgia, premenstrual syndrome, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, and sexually transmitted diseases.. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Donate today. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). Life Sci. Not only does red clover and cancer treat cancer but also … And they are going to start consuming it in very large amounts! Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Secondly, some of the types of cancer for which red clover has been traditionally used include cancers of the breast, uterus, ovaries, and prostate, for which estrogenic activity is considered to be contraindicated. More studies are needed. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Lethaby AE, Brown J, Marjoribanks J, et al. Red Clover Anti-Cancer Health Benefits. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … If your symptoms do not improve or if they become worse, contact your doctor or pharmacist as soon as possible. . Phytoestrogens for vasomotor menopausal symptoms. Red Clover herb is a simple to find herb with many uses. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.
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