Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations, and is a biomarker for toxic metal overload [29, 30, 31]. I haaven't found a thc prodcut that helps, yet. In animals, it decreased lead absorption into bone, and inhibited the action of the delta-aminolevulinic acid dehydratase (ALAD) enzyme . Lipoic acid is unique among other antioxidants because it is both water- and fat-soluble. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. Lipoic acid (LA), also known as alpha-lipoic acid (ALA), R-lipoic acid, or thioctic acid, is a disulfide-containing compound , found inside every cell of the body . In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … Press J to jump to the feed. It's not a "detox" reaction or from chelating heavy metals. Chelation is central to the natural detoxification of heavy metals, via the formation of complexes, particularly with glutathione and other small molecules, and their excretion . Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. Alpha lipoic acid (ALA) is a naturally-occurring antioxidant within the body, but you can obtain incorporate it in your daily diet in the form of supplements. Alpha lipoic acid is given in a dose of 300mg at least twice per day for hepatitis B or C. Alpha lipoic acid (ALA), silymarin, and selenium have been used in combination with success in reducing symptoms and elevated liver enzyme levels (though the viral load was not substantially reduced). CDN$ 35.99 CDN$ 35. Alpha-Lipoic acid is commonly referred to as ALA and Thiocitic acid. Anyone with personal experiences either with fixing mercury toxicity in general or using Cutler Therapy care to explain this discrepancy? (ii) Alpha-lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. https://www.amazon.com/R-Alpha-Lipoic-R-LIPOIC-count-STRENGTH/dp/B01M0QS5C7, There are many studies on its effectiveness available on the pubmed site. Clinical experience is that it must be used carefully as it poses particular risks of redistribution of metals. Symptoms: chronic sleep-maintenance insomnia (frequent (2-5) awakenings and low sleep time (avg 5.5hr rg 3-7hr), fatigue, brain fog, depression, anxiety, History: previously heavy fish diet with periods of >3 cans of tuna per week. Several supplements are also in use to address metal toxicities. Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid Common Name(s): Acetate replacing factor, Alpha-lipoic acid, Biletan, Lipoic acid, Lipoicin, Thioctacid, Thioctan, Thioctic acid : (i) Taurine [49, 50, 51] and methionine  are sulfur-containing amino acids. She did, and within a few months her memory problems vanished completely. ReddIt. Not only animals, but also plants produce chelating compounds , and the metallothionein content of foods may affect bioavailability, as well as metabolism of toxic metals . Alpha-lipoic acid is an antioxidant that's in many foods, and it's made naturally in our bodies. Trying to keep its serum levels elevated is a failed proposition, and in fact it doesn't even free-float, rather, it's bound to lipoproteins. In humans, organic selenium supplementation was beneficial in a controlled trial among 103 mercury-exposed villagers . Has anyone else tried this for neuropathy? Why do you think you have mercury toxicity? I have just began taking alpha-lipoic acid supplements, 300mg twice daily. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. On a lark I decided to google "alpha lipoic acid and multiple sclerosis," and sure enough, there's some early research indicating that it reduced the speed of brain volume loss in people with secondary progressive MS by 68%. Tried on and off twice. Sounds worth checking out. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. … R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. I’ve taken it at 600mg daily and had results within a few days. After some research, I suggested she try taking the maximum recommended dose of alpha lipoic acid, which is an antioxidant that affects the brain. You get small amounts of lipoic acid in your diet from spinach and collard greens, broccoli, beef and organ meats. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging . R-lipoic acid is directly involved in cellular metabolism and is a vital component of the intracellular antioxidant cycle, able to scavenge a variety of free radicals and reactive oxygen species (ROS) while recycling vitamins C, E and glutathione. 4.5 out of 5 stars 6. But lipoic acid declines in your body as you age. Selenium depletion in the face of mercury exposure also depletes seleno-enzymes. (i) Dietary fibers from various food products, including bran from grains, as well as fruit, have been evaluated as an alternative or adjunct to chelation therapy, with the aim to interrupt enterohepatic recirculation [34, 35, 36], and to modulate intestinal flora , with findings of reduced levels of mercury in the brain and blood. Some foods have been suggested to reduce absorption or reabsorption of toxic metals and to support natural detoxification pathways. "ALA should be admitted at least 2 hr after eating or if taken before; meal should be taken at least 30 min after ALA administration In addition, it has been suggested that acidic pH of the stomach is favorable for ALA absorption through the gastrum. This is a substantial difference. A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies . 300 mg of lipoic acid (of the R form of lipoic acid – see below for more detail) is recommended a day for diabetes management. Alpha-lipoic acid is an organic compound found in all human cells. The selenide ion forms an extremely stable, insoluble compound with mercury, and provides relief of mercurialism symptoms. A selenium yeast product increased mercury excretion and decreased oxidative stress-related biomarkers, particularly urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine . Metal-binding proteins, including metallothioneins, are potent chelators for heavy metals and are central to the natural response of the body to these toxic elements [27, 28]. (iii) Given that toxic metals have a great affinity for sulfur-containing peptides, diets rich in sulfur-containing foods, such as alliums (e.g. Alpha-lipoic acid is a natural protective antioxidant. The dosage of lyrica prescribed is not giving good results. ALA has been widely explored as a beneficial nutrient for a variety of bodily functions involving the nervous, cardiovascular, immune and detoxification systems. As long as you're healthy, the body can produce all the ALA it needs for these purposes. A friend was telling me about the antioxidant Alpha Lipoic Acid (ALA), and talking about how it can have anti-inflammatory effects. for evidence-based support, only the Cutler Therapy comes up. Alpha lipoic acid has been used successfully to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease. Results from certain studies demonstrate that long-term use of alphalipoic acid has beneficial effects on the development of retinopathy since it halts oxidative damage that can result in modified DNA in the retina. Worth the try though i suppose. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). But, there are few studies that refer to protective effects and potential mechanisms on traumatic brain injury (TBI). In accordance with the serotonin theory of depression, it may be possible to treat depression by increasing insulin activity. Glutathione is an important physiological chelator, and the reduced form of glutathione protects cells from reactive oxygen species (ROS) associated with heavy metals [58, 59, 60, 61]. Yes, I've had that exact thing from a. lipoic acid too. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. ALA is also beneficial in combating damages and infections that attack vital organs. garlic ) and brassicas (e.g., broccoli ) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. If you have confirmed that you have mercury toxicity, get a real chelating agent, preferably one actually backed by clinical evidence, and don't try an unproven treatment that doesn't sound likely to work and could be harmful. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Alpha lipoic acid (ALA) is a powerful antioxidant which has been widely used in the treatment of different system diseases, such as cardiovascular and cerebrovascular diseases. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. When looking up information about this to gather case studies/evidence/etc. Despite that fact, there has been a lot of recent interest in using ALA supplements. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Alpha-Lipoic Acid. It aids the body in breaking down sugar and using it to fuel energy. Has anyone else tried this for neuropathy? It serves vital functions at the cellular level, such as energy production. (iv) Cilantro (leaves of Coriandrum sativum), a popular culinary and medicinal herb, gained attention when a soup was reported to enhance mercury excretion following dental amalgam removal, and its use as a chelator remains popular despite limited evidence . Therefore, ALA supplements are preferably taken on an empty stomach to benefit of the acidic stomach pH. New comments cannot be posted and votes cannot be cast. * CDN$ 5.54 shipping. Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. Discussion of nootropics and cognitive enhancers. (iii) N-acetyl-cysteine (NAC), an orally available precursor of cysteine, is a chelator of toxic elements and may stimulate glutathione synthesis, particularly in the presence of vitamins C and E [54, 55, 56]. Some call it the “universal antioxidant” . This increased influx of tryptophan has been shown to result in an increase in serotonin synthesis. "This may explain why the results of trials are confusing.I'm going to have to change when I take mine. Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. The formula cannot be purchased directly from the manufacturer’s website. It may be administered intravenously, in creams, and via nebulizer. Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. * However, caution is merited regarding soluble fiber; in contrast to the protection offered by insoluble fiber, flaxseed has resulted in increased intestinal absorption of cadmium . Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. Garlic prevented cadmium-induced kidney damage  and decreased the oxidative damage due to lead in rats . * It has important characteristics that contribute to liver, nerve, and eye health. The lack of concrete clinical literature is unconcerning to me given the evidence surrounding alpha lipoic acid's structural similarities to tried and true chelators and the lack of financial motivation of pharma to study such a compound. Being both fat and water-soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers [22, 53]. Lipoic acid also prevents diabetic neuropathy characterized by pain, burning, and stabbing sensations in the extremities. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. Due to its potential antioxidant activity, … 5) Acetyl L-Carnitine and Alpha Lipoic Acid Price. Try taking alpha lipoic acid. Nonetheless, people claim moderate success using his regimen. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. I'm intrigued by Lipoic Acid as a potential chelator for mercury , as I suffer from chronic mercury toxicity. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Much higher doses for way longer periods of time and saw no change. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. That's just a side effect of how it affects people. Recently, an oral controlled‐release formulation of alpha‐lipoic acid (CRLA) was developed, and a pharmacokinetic study demonstrated that CRLA maintained significant plasma levels for 67% longer than a common quick‐release formulation. They are rich in membranes, particularly of excitable tissues, and they decrease oxidative stress markers resulting from heavy metal exposure. Even if ALA can chelate mercury, it's not a compound that sounds likely to get eliminated afterwards. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. reddit. Look do your research on it! I'm intrigued by Lipoic Acid as a potential chelator for mercury, as I suffer from chronic mercury toxicity. Good luck! Insights on the Use of α-Lipoic Acid for Therapeutic Purposeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318Here is a recent paper explaining what the researchers have tried using it for.Edit to add this quote from above paper. Effect of Alpha-Lipoic Acid Supplementation on Oxidative Stress Markers and Antioxidative Defense … I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Yes. Some make it worse. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. Press J to jump to the feed. Nothing else has helped other than narcotic pain meds or Neurontin, many years ago until the nasty side effects set it and became unable to take any of those drugs. 99. Therefore, the nutrient alpha lipoic acid should be clinically tested … Optim-ALA Optimized Alpha Lipoic Acid should provide and support optimal mitochondrial function, energy … Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. (ii) Other natural polymers have also been gaining attention as potential adsorbents of heavy metals, such as algal polysaccharides alginate  and chlorella . It is widely understood that alpha lipoic acid is manufactured endogenously within the human body and that its presence is essential for aerobic metabolism, or the means by which the body generates energy via breakdown of carbohydrates, amino … R-lipoic acid is the biologically active form of the key ‘mitochondrial antioxidant,’ alpha lipoic acid. The price of this product is moderate and can even be considered cheap in comparison with similar products. Alpha‐lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. Image: MedMD. This is a unique & common antioxidant available in … Alpha‐lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. Simply Nature's Pure Alpha Lipoic Acid RLA R-LA R-Lipoic S-Lipoic HIGHEST Quality ALA, Better Bioavailability also known as Thioctic Acid 120 Count 4 Month Supply. Alpha-lipoic acid is essential for certain enzymatic reactions, but there is no official recommended dietary intake of ALA . Optim-ALA Optimized Alpha Lipoic Acid utilizes two of the best, most bioavailable forms of R-ALA paired with sesame extract. What side effects did you experience from Neurontin? Yes. You need to be on R Alpha Lipoic Acid. Given the literature value, dosing according to Cutler Therapy would result in fluctuating between just over 100% and 1% blood levels, obviously suboptimal (and also below the clinical determination for elimination). A year ago my mother started suffering from some pretty obvious, and worrying memory loss. Alpha lipoic acid (ALA), also known as thioctic acid, is an eight-carbon organosulfur compound derived from caprylic acid (octenoic acid). Alpha Lipoic Acid: Half Life? A subreddit for those living with neuropathy. Acetyl L-Carnitine and Alpha Lipoic Acid is sold by bottles of 60 capsules, containing 650 mg. Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. On the face of it, selenide might not be compatible with chelation, as the two agents may counter the effectiveness of one another ; however, selenium may be incorporated in organic molecules, and organic selenium/mercury complexes may be transported through membranes. Jarrow Formulas R-Alpha Lipoic Acid, Supports Energy, Cardio Vascular Health, 100 mg, 60 Caps. It’s made inside the mitochondrion — also known as the powerhouse of cells — where it … Because it protects the endothelium, alpha lipoic acid reduces the risk of diabetic vascular disease and kidney disease. 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